Sulforaphane improves vascular reactivity in mouse and human arteries after “preeclamptic-like” injury
A Langston-Cox, CH Leo, M Tare, EM Wallace… - Placenta, 2020 - Elsevier
Introduction The widespread maternal endothelial dysfunction that underlies the
manifestations of preeclampsia is thought to arise from excessive placental production of
antiangiogenic factors and enhanced oxidative stress. Therefore, we assessed whether the
natural antioxidant sulforaphane could improve vascular function. Methods Cell viability of
human umbilical vein endothelial cells (HUVECs) was assessed after 24 or 48 h in normoxia
(20% O 2) or hypoxia (1% O 2) with or without sulforaphane. To model vascular dysfunction …
manifestations of preeclampsia is thought to arise from excessive placental production of
antiangiogenic factors and enhanced oxidative stress. Therefore, we assessed whether the
natural antioxidant sulforaphane could improve vascular function. Methods Cell viability of
human umbilical vein endothelial cells (HUVECs) was assessed after 24 or 48 h in normoxia
(20% O 2) or hypoxia (1% O 2) with or without sulforaphane. To model vascular dysfunction …
