Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring
A Boeszoermenyi, HM Nagy, H Arthanari… - Journal of Biological …, 2015 - ASBMB
Triacylglycerols (TGs) stored in lipid droplets (LDs) are hydrolyzed in a highly regulated
metabolic process called lipolysis to free fatty acids that serve as energy substrates for β-
oxidation, precursors for membrane lipids and signaling molecules. Comparative gene
identification-58 (CGI-58) stimulates the enzymatic activity of adipose triglyceride lipase
(ATGL), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids. In
adipose tissue, protein-protein interactions between CGI-58 and the LD coating protein …
metabolic process called lipolysis to free fatty acids that serve as energy substrates for β-
oxidation, precursors for membrane lipids and signaling molecules. Comparative gene
identification-58 (CGI-58) stimulates the enzymatic activity of adipose triglyceride lipase
(ATGL), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids. In
adipose tissue, protein-protein interactions between CGI-58 and the LD coating protein …
