[HTML][HTML] Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis
G Haemmerle, R Zimmermann, M Hayn… - Journal of Biological …, 2002 - ASBMB
Hormone-sensitive lipase (HSL) is expressed predominantly in white and brown adipose
tissue where it is believed to play a crucial role in the lipolysis of stored triglycerides (TG),
thereby providing the body with energy substrate in the form of free fatty acids (FFA). From in
vitro assays, HSL is known to hydrolyze TG, diglycerides (DG), cholesteryl esters, and retinyl
esters. In the current study we have generated HSL knock-out mice and demonstrate three
lines of evidence that HSL is instrumental in the catabolism of DG in vivo. First, HSL …
tissue where it is believed to play a crucial role in the lipolysis of stored triglycerides (TG),
thereby providing the body with energy substrate in the form of free fatty acids (FFA). From in
vitro assays, HSL is known to hydrolyze TG, diglycerides (DG), cholesteryl esters, and retinyl
esters. In the current study we have generated HSL knock-out mice and demonstrate three
lines of evidence that HSL is instrumental in the catabolism of DG in vivo. First, HSL …
