[HTML][HTML] CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid
AK Ghosh, G Ramakrishnan, C Chandramohan… - Journal of Biological …, 2008 - ASBMB
cgi-58 (comparative gene identification-58) is a member of α/β-hydrolase family of proteins.
Mutations in CGI-58 are shown to be responsible for a rare genetic disorder known as
Chanarin-Dorfman syndrome, characterized by an excessive accumulation of triacylglycerol
in several tissues and ichthyosis. We have earlier reported that YLR099c encoding Ict1p in
Saccharomyces cerevisiae can acylate lysophosphatidic acid to phosphatidic acid. Here we
report that human CGI-58 is closely related to ICT1. To understand the biochemical function …
Mutations in CGI-58 are shown to be responsible for a rare genetic disorder known as
Chanarin-Dorfman syndrome, characterized by an excessive accumulation of triacylglycerol
in several tissues and ichthyosis. We have earlier reported that YLR099c encoding Ict1p in
Saccharomyces cerevisiae can acylate lysophosphatidic acid to phosphatidic acid. Here we
report that human CGI-58 is closely related to ICT1. To understand the biochemical function …
