DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli
Y Kato, T Kawamoto, K Fujimoto, M Noshiro - Current topics in …, 2014 - Elsevier
Daily physiological and behavioral rhythms are regulated by endogenous circadian
molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the
basic helix–loop–helix protein superfamily, which contains other clock proteins CLOCK and
BMAL1. DEC1 and DEC2 are induced by CLOCK: BMAL1 heterodimer via the CACGTG E-
box in the promoter and, thereafter, suppress their own expression by competing with
CLOCK: BMAL1 for the DNA binding. This negative feedback DEC loop together with the …
molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the
basic helix–loop–helix protein superfamily, which contains other clock proteins CLOCK and
BMAL1. DEC1 and DEC2 are induced by CLOCK: BMAL1 heterodimer via the CACGTG E-
box in the promoter and, thereafter, suppress their own expression by competing with
CLOCK: BMAL1 for the DNA binding. This negative feedback DEC loop together with the …
