Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera
A Muik, BG Lui, AK Wallisch, M Bacher, J Mühl… - Science, 2022 - science.org
A Muik, BG Lui, AK Wallisch, M Bacher, J Mühl, J Reinholz, O Ozhelvaci, N Beckmann…
Science, 2022•science.orgThe globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant of concern Omicron (B. 1.1. 529) has a large number of mutations, especially in the
spike protein, indicating that recognition by neutralizing antibodies may be compromised.
We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B. 1.351), Delta (B. 1.617. 2), or
Omicron pseudoviruses with sera of 51 participants who received two or three doses of the
messenger RNA (mRNA)–based COVID-19 vaccine BNT162b2. After two doses, Omicron …
variant of concern Omicron (B. 1.1. 529) has a large number of mutations, especially in the
spike protein, indicating that recognition by neutralizing antibodies may be compromised.
We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B. 1.351), Delta (B. 1.617. 2), or
Omicron pseudoviruses with sera of 51 participants who received two or three doses of the
messenger RNA (mRNA)–based COVID-19 vaccine BNT162b2. After two doses, Omicron …
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be compromised. We tested Wuhan (Wuhan-Hu-1 reference strain), Beta (B.1.351), Delta (B.1.617.2), or Omicron pseudoviruses with sera of 51 participants who received two or three doses of the messenger RNA (mRNA)–based COVID-19 vaccine BNT162b2. After two doses, Omicron-neutralizing titers were reduced >22-fold compared with Wuhan-neutralizing titers. One month after the third vaccine dose, Omicron-neutralizing titers were increased 23-fold relative to their levels after two doses and were similar to levels of Wuhan-neutralizing titers after two doses. The requirement of a third vaccine dose to effectively neutralize Omicron was confirmed with sera from a subset of participants using live SARS-CoV-2. These data suggest that three doses of the mRNA vaccine BNT162b2 may protect against Omicron-mediated COVID-19.
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