Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and …

R Demir, UA Kayisli, Y Seval, C Celik-Ozenci… - Placenta, 2004 - Elsevier
Vascularization within the human placenta is the result of the de novo formation of vessels
derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization
of placental villi starts at around day 21 post conception (pc) with a four somite embryo. At
this stage progenitors of haemangiogenic cells differentiate to form first vessels. These
progenitor cells are thought to be directly derived from mesenchymal cells rather than
originating from fetal blood cells. We investigated the relation between differentiation of …