[HTML][HTML] The histone deacetylase inhibitor romidepsin spares normal tissues while acting as an effective radiosensitizer in bladder tumors in vivo
Purpose Muscle-invasive bladder cancer has a 40% to 60% 5-year survival rate with radical
treatment by surgical removal of the bladder or radiation therapy–based bladder
preservation techniques, including concurrent chemoradiation. Elderly patients cannot
tolerate current chemoradiation therapy regimens and often receive only radiation therapy,
which is less effective. We urgently need effective chemotherapy agents for use with
radiation therapy combinations that are nontoxic to normal tissues and tolerated by elderly …
treatment by surgical removal of the bladder or radiation therapy–based bladder
preservation techniques, including concurrent chemoradiation. Elderly patients cannot
tolerate current chemoradiation therapy regimens and often receive only radiation therapy,
which is less effective. We urgently need effective chemotherapy agents for use with
radiation therapy combinations that are nontoxic to normal tissues and tolerated by elderly …
