Aerosolized pancreatic dornase and antibiotics in pulmonary infections: use in patients with postoperative and nonoperative infections
R Spier, E Witebsky, JR Paine - Jama, 1961 - jamanetwork.com
This study was undertaken to determine whether an enzyme, pancreatic dornase, plus an
antibiotic aerosolized for endobronchial application via the intermittent positive pressure
breathing/inspiration machine would be a valuable adjunctive measure to systemic
antibiotics in the treatment of pneumonias. Thirty patients with pneumonia have been
successfully treated by this method. Half of these patients had staphylococcal pneumonia
(some with lung abscesses). Pancreatic dornase was effective in lysing the endobronchial …
antibiotic aerosolized for endobronchial application via the intermittent positive pressure
breathing/inspiration machine would be a valuable adjunctive measure to systemic
antibiotics in the treatment of pneumonias. Thirty patients with pneumonia have been
successfully treated by this method. Half of these patients had staphylococcal pneumonia
(some with lung abscesses). Pancreatic dornase was effective in lysing the endobronchial …