Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption
T Miyazaki, M Iwasawa, T Nakashima, S Mori… - Journal of Biological …, 2012 - ASBMB
Osteoclasts, highly differentiated bone-resorbing cells of hematopoietic origin, have two
conflicting tendencies: a lower capacity to survive and a higher capacity to execute energy-
consuming activities such as bone resorption. Here, we report that when compared with their
precursors, mature mitochondria-rich osteoclasts have lower levels of intracellular ATP,
which is associated with receptor activator of nuclear factor κ-B ligand (RANKL)-induced Bcl-
x L down-regulation. Severe ATP depletion, caused by disrupting mitochondrial transcription …
conflicting tendencies: a lower capacity to survive and a higher capacity to execute energy-
consuming activities such as bone resorption. Here, we report that when compared with their
precursors, mature mitochondria-rich osteoclasts have lower levels of intracellular ATP,
which is associated with receptor activator of nuclear factor κ-B ligand (RANKL)-induced Bcl-
x L down-regulation. Severe ATP depletion, caused by disrupting mitochondrial transcription …
