Leptin applications in 2015: what have we learned about leptin and obesity?
OM Farr, A Gavrieli, CS Mantzoros - Current Opinion in …, 2015 - journals.lww.com
OM Farr, A Gavrieli, CS Mantzoros
Current Opinion in Endocrinology, Diabetes and Obesity, 2015•journals.lww.comLeptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways
involved in leptin resistance are continuously discovered, whereas the development of new
techniques and drug combinations which may improve leptin's efficacy and safety
regenerate the hope for its use as an effective treatment for typical obesity.
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways
involved in leptin resistance are continuously discovered, whereas the development of new
techniques and drug combinations which may improve leptin's efficacy and safety
regenerate the hope for its use as an effective treatment for typical obesity.
Summary
Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways involved in leptin resistance are continuously discovered, whereas the development of new techniques and drug combinations which may improve leptin's efficacy and safety regenerate the hope for its use as an effective treatment for typical obesity.
Lippincott Williams & Wilkins